Decoding monocyte metabolism in myocardial infarction a time-sensitive approach to limiting heart failure

The HOSPICES CIVILS DE LYON in Belgium from Europe region has released this tender for Decoding monocyte metabolism in myocardial infarction a time-sensitive approach to limiting heart failure Cardiovascular diseases CVD particularly myocardial infarction MI are partly driven by chronic inflammation in which myeloid cells such as monocytes and macrophages play a central role This project aims to elucidate the metabolic mechanisms regulating monocyte function and their impact on post-MI recovery Emerging evidence suggests that the metabolic state of myeloid progenitor cells and their descendants critically influences their pro- or anti-inflammatory functions While glycolysis dominates early after MI fatty acid oxidation takes over later stages indicating that metabolic reprogramming is essential for monocyte and macrophage function In this project we will investigate the metabolic signatures of monocytes at different time points post-MI using a preclinical mouse model and the human HIBISCUS STEMI cohort We aim to identify key metabolic pathways that can be targeted to modulate inflammation by employing single-cell RNA sequencing and single-cell metabolic assays In mouse models we will further test the effects of transiently inhibiting glycolysis or fatty acid oxidation in monocytes using genetically modified mice to determine whether this approach improves cardiac function and limits heart failure Additionally the fellowship will provide essential soft skills training in project management mentoring and grant writing which are crucial for my transition to an independent research position These skills will enhance my leadership abilities and prepare me for future academic and industrial opportunities This research will provide new insights into the role of metabolism in myelopoiesis and inflammation and could lead to novel therapeutic strategies to improve outcomes in CVD patients with tender notice no. 101210952 published on 12 May 2025. The tender is due to expire on 30 Jun 2027. This tender is sourced from Cordis and is eligible for suppliers interested in Miscellaneous medical devices and products. Interested bidders can obtain further information including complete bid documents or ways to participate by registering on Tender Impulse and referencing via Tender Impulse ID 7909341.