Local and systemic mechanisms for metabolic inflammation chronicity

The TECHNISCHE UNIVERSITAET DRESDEN in Belgium from Europe region has released this tender for Local and systemic mechanisms for metabolic inflammation chronicity Chronic inflammation underlies several diseases and is a common basis of multiple comorbidities In obesity chronic inflammation of the adipose tissue AT and liver contributes to the metabolic syndrome and related metabolic-inflammatory pathologies Here we propose a thorough and innovative approach to revolutionize understanding of metabolic inflammation chronicity We will address both local at the respective tissue level and systemic mechanisms involving the novel principle of trained innate immunity TII and inflammatory adaptation of the bone marrow BM i Local In chronic metabolic inflammation there is an imbalance between chronic accumulation activation of inflammatory cells and resolution of inflammation RoI in favor of the former Based on our recent findings regarding integrin-dependent chronic macrophage retention in the obese AT and that Developmental endothelial locus-1 promotes RoI we will here identify novel pathways towards counter-acting chronicity of metabolic inflammation and facilitating its resolution and test their therapeutic efficacy ii Systemic Systemic metabolic inflammatory feedback to the BM may trigger long-term adaptations of hematopoietic progenitors fueling a feed-forward loop of perpetual inflammation Following our discovery that TII is initiated in the BM we will pursue the hypothesis that maladaptive training of BM progenitors in obesity facilitates metabolic inflammation chronicity via generation of myeloid cells with higher potential for tissue accumulation and inflammatory activation and promotes development of obesity-related inflammatory comorbidities Despite apparent links local and systemic mechanisms are mostly studied independently of each other rather than through an integrative approach which will be followed here for the first time Our proposal will lead to breakthrough concepts in metabolic inflammation chronicity and to novel therapeutic strategies for metabolic-inflammatory pathologies with tender notice no. 101055377 published on 12 Aug 2026. The tender is due to expire on 29 Feb 2028. This tender is sourced from Cordis and is eligible for suppliers interested in Health services. Interested bidders can obtain further information including complete bid documents or ways to participate by registering on Tender Impulse and referencing via Tender Impulse ID 14330352.